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Pioglitazone also attenuated endothelin-1–induced vasoconstriction by downregulating cyclooxygenase-2 (COX-2) via activator protein-1 (AP-1) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), while enhancing NO bioavailability [148]
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Dosering:12.5 mg (4 injecties per pen)
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